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406,407 Interestingly, IDH1 mutants compete for NADPH to synthesize 2-HG with other pathways that are critical for cell viability, resulting in further disruption of cellular metabolism and redox homeostasis in tumorigenesis

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doi: 10.1016/j.jds.2024.09.021 180 RuanJWeiXLiSYeZHuLZhuangRet al