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Although the effect of arginine supplementation remains to be tested, many studies have demonstrated that the downregulation of TCR receptor complex subunit CD3 in T cells cultured under arginine-restricted conditions leads to the restriction of T cell proliferation

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Peterson et al., 1998)

Additionally, TB-500 has been found to exhibit immunomodulatory effects by preventing apoptosis through cytochrome c release inhibition and modulation of BCL-2 expression and caspase activation [10]

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Presenting clinical signs include vomiting, diarrhea, and weight loss with increased or decreased appetite