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This is proposed to be mediated by TRX1 oxidation by hydrogen peroxide which causes dissociation of ASK1 thereby triggering anti-apoptotic factors via downstream activation of MAPK kinase MKK3/MKK6/p38 and MKK4/MKK7/JNK pathways (Wagner et al

Mol Neurodegener 17(1):23 Mustafa YF (2025) Coumarins at the crossroads of drug development: enzyme modulation for clinical advances

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Additionally, ensure full compliance with local regulations, ethical standards, and institutional policies before initiating any study