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The enzyme-catalyzed reverse reaction between GSSG or GSSR and reduced roGFP2 releases roGFP2(SSG) which can instantaneously react via a nonenzymatic shortcut yielding GSH and roGFP2(S 2 ) (Fig

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Melatonin enhances the synthesis and recycling of glutathione (GSH), a major intracellular antioxidant critical for controlling redox-sensitive signaling pathways ( Gclc ( - , a pathway also reported to be enhanced by melatonin in airway epithelial cells ( In this study, we investigated the role of melatonin in regulating ILC2-dependent allergic airway inflammation