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Most dosing is done in the evening, before sleep onset, because the aim is to induce sleep or promote deep sleep

As the HPT axis has long been involved in the research of depression (106), it is reasonable to believe that the dysfunction of the HPT axis in GD, with its effect of disrupting neurotransmitter metabolism, inducing oxidative stress, contributing to other complications and so forth, has a potentially vital effect on the development of depression

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(10) yielded similar results and also mentioned that the IOP of diabetic cataract patients was higher than other cataract patients

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