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The redox behavior of the NAD + /NADH system is therefore influenced by 1) the pH of the solution, since hydrogen ions participate in the redox half-reaction, 2) the 8 protonation states of NAD + , due to its three basic moieties, 3) the 16 protonation states of NADH, due to its four basic moieties (two pyrophosphate moieties, an adenine ring, and an added dihydropyridine ring)

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and M.L.H., B.B., C.H., K.J.M., A.H., Q.W., Y.D., N.C.S., and M.K.T

This type evolves over the years and may be mistaken for sunspots or age spots