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It is important to note that confirmation of ferroptosis in erythrocytes can be challenging due to the impossibility to assess characteristic alterations of organelles (especially mitochondria, absent in mature RBCs) and the complex ferroptosis signaling requiring epigenetic, transcriptional, and post-translational regulation

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A., Cheng, L., & Huang, W

The connection between abnormal iron metabolism in tumor stem cells and iron dependent deathhighlights the potential of iron dependent deathas a promising target in combating tumor stem cells, enhancing treatment efficacy, and reversing drug resistance (Xu et al., 2023)

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