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This may accelerate the repair cascade

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Although the SPH domain alone cannot activate c-MET, mutations that disrupting the interaction between HGF-SPH and c-MET-SEMA significantly reduce HGF-induced c-MET activation, validating the functional importance of this interaction 15

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Rodent studies lasting up to 90 days show no significant adverse events at doses up to 10 mg/kg, but no human safety data exist for BPC-157 in any indication, including gastroparesis