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Structural Modification 1: Amyloid-Resistant Scaffold Substitutions at Residues 20-29 The aggregation-prone segment of native amylin (residues 20-29) was redesigned in cagrilintide through targeted amino acid substitutions

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Aviram M, Billecke S, Sorenson R, Bisgaier C, Newton R, Rosenblat M, Erogul J, Hsu C, Dunlop C, La Du B