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Perturbation of this axis, either through direct GPX4 inhibition or GSH depletion via impaired cystine import (for example, via system Xc inhibition), markedly sensitizes cells to ferroptotic death (1,16)

Animal studies have shown it to be cytoprotective against known carcinogens

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doi: 10.1039/D2BM01915A 21 LanY.ZhouJ.XuK

It ranked as the 14th most common allergen in patch tests from 200506