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10.1074/jbc.RA119.012144 Summary Keywords Klotho, controversy, biomarker, chronic kidney disease, diagnosis, and prognosis Citation Yu L-X, Li S-S, Sha M-Y, Kong J-W, Ye J-M and Liu Q-F (2022) The controversy of klotho as a potential biomarker in chronic kidney disease

Animal models of colitis have demonstrated that GLP-1 receptor activation may reduce intestinal inflammation through multiple mechanisms, including modulation of pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-) and interleukin-6 (IL-6), enhancement of intestinal barrier function, and reduction of oxidative stress

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Conclusion The latest trials from 2025 confirm that cardiovascular outcomes in diabetes are as important as glycemic control