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8 Its for people who have already reached and tolerated 2.4 mg, and its currently available privately rather than on the NHS

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doi: 10.1186/s40104-018-0298-1 7 AlkhashabA

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Chronic exposure to loop diuretics induces structural and functional changes in the distal nephron, including hypertrophy and hyperplasia of epithelial cells, upregulation of sodium-chloride cotransporters, and activation of the epithelial sodium channel (ENaC)