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In a randomized, double-blind, placebo-controlled trial in 2,919 participants (65 years) with elevated blood concentrations of homocysteine, supplementation with vitamin B 12 (500 g/day) and folic acid (400 g/day) for two years did not decrease the risk of osteoporotic fracture despite reductions in homocysteine (120, 121)
By maintaining balanced homocysteine levels, B12 can lower the risk of heart-related conditions
February 17, 2026 Ive been ordering from them for several years, never had any issues
PMCID: PMC9687310
Category 1 status only means a substance is eligible for use by 503A compounding pharmacies pending final FDA rulemaking
when present, symptoms typically reflect underlying conditions such as liver disease, haematological disorders, or renal impairment rather than the elevated vitamin itself
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