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Erythrocytes and the Pentose Phosphate Pathway The predominant pathways of carbohydrate metabolism in the red blood cell (RBC) are glycolysis, the PPP and 2,3-bisphosphoglycerate (2,3-BPG) metabolism (refer to discussion of hemoglobin for review of the synthesis and role role of 2,3-BPG)

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A rare cause of neonatal hemolytic anemia: glutathione synthetase deficiency

In fact, mitochondrial iron chelation induced by mitochondrially targeted deferoxamine (DFO) decreased ISC and heme levels, impaired OXPHOS and ATP production and decreased tumor proliferation [42]