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Beyond pharmacological and exercise-bases interventions, novel approaches such as transcranial magnetic stimulation (TMS), have been shown to modulate neuronal activity within circuits regulating feeding behavior and satiety (52)

A trial showed higher abstinence rates (OR 6.3) versus placebo, and studies indicate it is acceptably safe, though side effects like fatigue and sedation may be problematic, especially in hepatic encephalopathy [125,126]

Effect of hypo-and hyperthyroidism on regional monoamine metabolism in the adult rat brain

Peripheral cytokine and chemokine alterations in depression: a meta-analysis of 82 studies

doi: 10.3389/fimmu.2025.1622744