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To me, the most important thing is that we need drugs that are scalable and accessible to the vast majority, not just within high-income countries, but the rest of the world, where obesity is rising again because of rapid changes in the environment

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Despite these promising results, unanswered questions regarding the role and mechanisms of tirzepatide and other incretin-based therapy in the treatment of OSA remain

This suggests a role for HLAs in stratifying the risk of irAEs, identifying a group that requires more intensive monitoring