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Rapid muscle loss during Retatrutide treatment can compromise functional capacity, especially in older adults

Cardiovascular benefits The SELECT trial a landmark cardiovascular outcomes study involving over 17,000 participants showed that semaglutide reduced the risk of major cardiovascular events (heart attack, stroke, cardiovascular death) by 20% in people with obesity who did not have diabetes

For women, this shift may unmask genetic susceptibility to androgenic alopecia that was previously masked by higher estrogen levels

0315-00025949-1 April 2015 Logo - Photo - Photo - Logo - Photo - SOURCE Novo Nordisk Inc.

Rodriguez 2025 (EHR, n=125,474): 1-year discontinuation 64.8% in non-diabetics vs 46.5% in type 2 diabetes

However, potential side effects like gastrointestinal discomfort were noted, emphasizing the need for medical guidance