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When you inject a cold substance into your body, which is at a steady 98.6 degrees Fahrenheit, the temperature difference can trigger a sharp, stinging sensation

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In addition, lactulose converts freely diffusible ammonia into non-absorbable ammonium ions, thereby reducing intestinal ammonia absorption, while its cathartic effect enhances fecal nitrogen excretion and lowers systemic ammonia levels [122]

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