Concurrent lifestyle drift compounds this effect
Data from bariatric surgery research (similar magnitude of weight loss) shows 2-8% bone density reduction in the first year without intervention
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Second, semaglutide slows down how quickly the stomach empties food
Steffen, Lees, and Booth [77] reported that the administration of either soluble TNF receptor-1 or the general inhibitor of TNF- production, pentoxifylline, attenuated losses in both body and skeletal muscle mass, and also reduced increases in ubiquitin proteasome pathway transcripts in an animal model of cardiac cachexia
More serious but rare risks include pancreatitis, gallbladder problems, and the theoretical thyroid cancer risk seen in rodent studies (not confirmed in humans at therapeutic doses, but it is why the thyroid cancer history exclusion exists)