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The high cost and large potential patient population for GLP-1 medications threaten the budgets of insurers and states

7f,g), indicating that the ring moiety of ava 2 C has similar characteristics to L 18

Previous RNA sequencing data analysis showed that neurons and astrocytes express distinct splice isoforms of the PKM gene PKM1 and PKM2 , respectively 48

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[1] Individual variation is considerable

Expiry and Opportunities Timeline:2026: Base patents lapse in China and Brazilgenerics loom, with 15 Chinese firms in trials.2031: 343 patent ends in the U.S.a key hurdle falls.2033+: Formulation/use patents delay full competition