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383 Compared with regorafenib, clinical trials combining vorinostat and hydroxychloroquine in metastatic CRC (NCT02316340) have shown immune enhancement but reduced progression-free survival, 384 whereas a separate phase I trial (NCT01023737) confirmed safety in solid tumors

Results GSDMD-mediated pyroptosis is activated in ischemic hindlimbs To investigate the involvement of GSDMD-mediated pyroptosis in hindlimb ischemic injury in vivo, we established hindlimb ischemia (HLI) model by ligation of the femoral artery in wild-type (WT) mice

Adv Ther 26(1):4054

Blood-brain barrier crossing is unconfirmed for peripherally administered DSIP

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