Tirzepatide uses a 39-amino-acid sequence with a fatty acid chain attachment that binds to albumin in the bloodstream, slowing clearance and creating the roughly 5-day half-life that makes weekly dosing practical
Some antidepressants, particularly certain SSRIs and tricyclics, can increase appetite or affect metabolism
Clinical trials have shown body weight reductions of 15 to 20% in some participants, which explains why these medications have exploded in popularity beyond diabetes treatment (Wilding et al., 2021, New England Journal of Medicine)
The right thing would be to ensure that the pharmacies (and their suppliers) that risked so much to keep the public supplied during the shortage crisis are at least permitted to sell through their remaining inventory
Earlier this year, Ro launched the GLP-1 Supply Tracker, an open-access tool set up to help patients and providers keep track of which GLP-1 medications are in stock and which are in shortage
& Scott, L
