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Our paradigm also did not require food deprivation: in contrast to several previous laboratory-based experiments (e.g., [51, 52]), the animals were allowed to eat in an unrestrained and practically ad libitum manner (see Methods)

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A recent study yielded additional model predicted targets after including lipid requirements 83

Initial gains may come quickly as inflammation decreases and blood flow improves, but the deeper tissue remodeling required for lasting resolution takes longer