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The numbers below come from two places: rodent studies scaled to a human size (allometric scaling) and several years of research community use reports

Ease of use: PT-141 nasal spray is considerably easier to use and administer, as it can be conveniently sprayed in the nostrils

Medical writing support for the development of this manuscript, under the direction of the authors, was provided by Holly Williams, of Ashfield MedComms, an Inizio company

The safety problem is not the combination

Not necessarily - even smaller amounts of prebiotic fiber feed gut bacteria and support the fermentation pathway