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pH extremes destabilize the copper complex

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This phenomenon could be due to the fact that, after reaching a certain particle size, the GSH as stabilizer was able to withhold the nanoparticles size effectively

While analyses restricted to participants with established cardiovascular disease yielded MACE results that were directionally consistent with the overall analysis, conclusions are limited because subgroup estimates were based on trial-level reporting rather than individual participant data, and included studies continued to differ in patient characteristics, definitions of established cardiovascular disease, background therapies, and trial era