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Dose-by-dose weight loss in Phase 2 (NEJM) Phase 2 NEJM weight loss by dose, 24 and 48 weeks Dose 1 mg 24 weeks -7.2% 48 weeks -8.7% Dose 4 mg 24 weeks -12.9% 48 weeks -17.5% Dose 8 mg 24 weeks -15.7% 48 weeks -22.8% Dose 12 mg 24 weeks -17.5% 48 weeks -24.2% Dose Placebo 24 weeks -1.6% 48 weeks -2.1% Source: Jastreboff et al., NEJM 2023

Although real-world flexibility can benefit some patients, it should not replace evidence-based protocols entirely

Among the 12mg group, 58.6% achieved 25% or greater weight loss, 39.4% achieved 30% or greater, and 23.7% achieved 35% or greater

Dosing frequency and administration preferences significantly impact adherence and patient satisfaction

Itll feel slow sometimes but just keep doing the little things that you can, little walks etc add up

Does health insurance cover them