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Adapted from references (1,37) GH binds to the extracellular component of the hepatic GH receptor (GH-R) and induces a series of intracellular processes required for the transcription and translation of specific genes that encode insulin-like growth factor 1 (IGF1), IGF-binding protein 3 (IGFBP3), and an acid-labile subunit (ALS)(810)

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Since then, this has been reaffirmed and expanded on in repeated peer-reviewed clinical studies

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Antioxidant systems like SOD and glutathione peroxidase (GPx) reduce OH generation by scavenging O 2 and HO, thereby lowering oxidative stress and inhibiting pyroptosis [232]

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