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The survey aimed to capture participants experiences with GLP1 receptor agonist medication, and was targeted to 23andMe participants who had previously responded in the affirmative to the question, Have you ever taken prescription medications to help you lose weight?

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In a phase I clinical trial, bivamelagon was given to obese and overweight participants in SAD and MAD arms of the trial (NCT06040372) (101, 102)

These effects were mediated through the secretion of various biologically active mediators, such as growth factors and anti-apoptotic cytokines, modulation of intra-ovarian signaling pathways, promotion of angiogenesis, and improvement in blood perfusion to damaged ovarian tissues [137]