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Estrogen-driven collagen decline accelerates during perimenopause, and substrate is typically already more depleted at baseline

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After a period of approximately 3 days, the culture media was gathered and analyzed for collagen type I content

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A 12-week trial showed that subjects receiving 1 mg per day of AOD 9604 lost an average of 2.6 kilograms compared to 0.8 kilograms in the placebo group

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