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This creates a self-reinforcing pro-inflammatory microenvironment that further impairs follicular development and oocyte developmental competence, linking cellular aging at the molecular level to clinically observable reproductive decline [185, 205]
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Estas terapias han demostrado eficacia al disminuir la concentracin de HbA1c, glucemia plasmtica y glucemia postprandial, mejorando el control glucmico de estos pacientes, sin embargo, los efectos en la mortalidad cardiovascular difieren en los dos grupos farmacolgicos presentes donde la liraglutida, un agonista del receptor GLP-1 (GLP-1R), demostr recientemente en el ensayo clnico denominado LEADER un beneficio cardiovascular, que es equivalente al recientemente constatado por los inhibidores del SGLT-2 4
SR-B1, which is involved in cholesterol uptake in the intestine and may play an important part in intestinal chylomicron production, and the fatty acid transporter CD36, which is also involved in the uptake of oxidised LDL, are members of the class B scavenger receptor family [52]
The effects of short-chain fatty acids on the cardiovascular system
