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There is not enough evidence (ie, controlled trials) to back safety and efficacy, one respondent writes

Structure of the protein kinase Cbeta phospholipid-binding C2 domain complexed with Ca 2+ Structure 1998

For example, the BNF notes that pancreatin can reduce the effect of acarbose (an antidiabetic medication) [13] [14] Allergic reactions : Many products are derived from animal (often porcine) or fungal sources and may trigger sensitivities or have religious implications Gastrointestinal irritation : High-dose enzyme supplements may worsen nausea or abdominal discomfort in some individuals Masking underlying conditions : Self-treating with supplements may delay diagnosis of serious digestive disorders Before purchasing any supplement, check the ingredient list carefully for allergens and avoid products making exaggerated health claims

A potential pathophysiological mechanism is differences in FFA metabolism and thus the concentration of FFA that the -cells are exposed to

If this information is important for your health decisions, you may wish to consider retesting or confirming this variant through a targeted genetic test or sequencing method