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Key Takeaways Menopause weight gain is driven by falling estrogen, rising insulin resistance, higher cortisol, and muscle loss, not a lack of effort

Anton J

Patients tapering should start the resistance program before the taper begins, not after, so the metabolic protection is in place before appetite rebounds

Due to the instability and lack of commercial GSSH standards, an urgent task is to develop methods for its in situ generation and quantification in various test systems

GI-related events may occur under rapid introduction or elevated dosing, typically mitigated through controlled administration protocols

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