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The oxidative branch of the PPP consists of three irreversible steps and is regulated by cellular NADPH levels

One study in particular has shown that the antioxidants glutathione and paraoxonase are lower in ADHD patients which may cause cellular injury, for example, around the central nervous system and in relation to dopamine production, (6)

It primarily acts by blocking voltage-dependent sodium channels and enhancing the activity of GABA, an inhibitory neurotransmitter

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However, the 2012 Prohibited List introduced a change: Intravenous infusions and/or injections of more than 50 mL per 6 hour period are prohibited except for those legitimately received in the course of hospital admissions or clinical investigations