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Those engaging in physical activity, living in hot climates, or experiencing increased urination (common with hyperglycemia or SGLT2 inhibitor medications) require additional hydration beyond baseline recommendations

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therefore, estradiol cypionate is generally avoided in nursing mothers, particularly during the early postpartum period, unless potential maternal benefits clearly outweigh possible effects on infant growth or hormonal exposure

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Safety Profile The safety profile of orforglipron across its Phase 2 and Phase 3 clinical development program has been consistent with the established safety characteristics of the GLP-1 receptor agonist class