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PCS also induces apoptosis and autophagy by activating NF-B and MAPK signaling and increasing the phosphorylation of extracellular signal-regulated kinase (ERK), p38, and c-Jun N-terminal kinase (JNK) in HK-2 cells ( Figure 3 ) [117]

JAMA Network Open, 6(5), e2314493

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Recent studies show that individuals with reduced or mutated VDR expression exhibit elevated malondialdehyde (MDA) levels and decreased GSH/GSSG ratios in the skin, indicative of impaired antioxidant capacity and reaffirming the centrality of VDR signaling in maintaining redox homeostasis

It signals your body to start producing fresh, new collagen and also causes the existing collagen fibers to contract and tighten