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In knee osteoarthritis, the cartilage gradually wears away, and the protective space between the bones of the joint decreases resulting in friction, stiffness, pain and inflammation

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Information about case ascertainment was not provided for eight studies [48, 49, 54, 59, 74, 78, 81, 84]

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p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype

received advisory/consulting fees and/or other support from Altimmune, AstraZeneca, Bayer, Biomea, Boehringer Ingelheim, Carmot Therapeutics, Cytoki Pharma, Eli Lilly, Intercept, Janssen/Johnson & Johnson, Mannkind, Mediflix, Merck, Metsera, Novo Nordisk, Pharmaventures, Pfizer, Regeneron, Sanofi, Shionogi, Structure Therapeutics, Target RWE, Terns Pharmaceuticals, The Comm Group, Valeritas, WebMD and Zealand Pharma