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It's important to note that weight loss itself is an evidence-based therapy for GERD, so the weight reduction achieved with these medications may actually improve reflux symptoms in some patients, potentially offsetting any direct effects on the gastroesophageal junction

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Regulation of Ferroptosis through GPX4 GPX4 was first recognized in 2014 as a key regulator of ferroptotic cell death by Yang et al

As the disease progresses, diminishing levels of FABP1 potentially leads to increased levels of lipids, with ensuing lipotoxicity promoting disease progression by damaging essential organelles and cells in the liver (Fig