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10.1007/s12011-020-02515-y 71 WangX.HanY.ChenF.WangM.XiaoY.WangH.et al (2022)

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However, trials using recombinant IGF peptides or complexes to treat age-related bone disease have been limited by lack of strong anabolic activity, and significant off-target actions such as hypoglycemia and the potential for malignant transformation

Together with the absence of symptoms associated with IGF-1-mediated effects such as fluid retention, tissue edema, or impaired glucose tolerance, these results demonstrate that AOD-9604 does not activate the growth hormone/IGF-1 pathway and therefore functions through an entirely appetite-independent mechanism

When it is finally released, its availability must be more strictly controlled than semaglutide to avoid similar life-threatening usage. Dr Marie Spreckley, of the MRC epidemiology unit at the University of Cambridge, said: Higher discontinuation due to adverse events, particularly gastrointestinal symptoms, is a key consideration and may have implications for tolerability and adherence in real-world settings. She added that because the trial lasted only one year, longer-term safety, cardiovascular outcomes and sustained effectiveness remained important unanswered questions