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This experience is so powerful that, for some, the food noise suppression becomes more meaningful than the weight loss itself

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In the COMBINE 3 trial in individuals with T2D inadequately controlled on daily basal insulin, IcoSema provided non-inferior reduction in HbA 1c from baseline to week 52 and superior body weight change and rate of combined clinically significant or severe hypoglycemia compared with basal-bolus insulin treatment that included once-daily insulin glargine U100 and insulin aspart given two to four times per day with main meals [15]

It can also be used as a weight management drug in patients with type 2 diabetes