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Studies have shown that AS-IV downregulates the expression of intestinal fibroblast growth factor 15, activates the liver farnesoid X receptor (FXR) signaling pathway, upregulates glucagon-like peptide-1, and reduces ceramide production, thereby modulating lipid synthesis processes that regulate cholesterol transport and optimize lipid metabolism in the liver (Zhai et al., 2022)

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Exenatide is found in the saliva of the Gila monster and exhibits all the effects of naturally occurring GLP- 1 [87]

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doi: 10.1016/j.cell.2014.10.039 92 KesikaP.SuganthyN.SivamaruthiB