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Differential importance of glucose-dependent insulinotropic polypeptide vs glucagon-like peptide 1 receptor signaling for beta cell survival in mice

Brain insulin resistance: role in neurodegenerative disease and potential for targeting

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It makes your pancreas release insulin when your blood sugar goes up, which lowers your blood sugar back to normal, so you can reach blood sugar stability with type 2 diabetes

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A key driver of this process is insulin resistance, which affects both hepatic and peripheral tissues, creating a metabolic environment that simultaneously promotes hyperglycemia and hepatic steatosis through selective pathway activation