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Lead author Thomas Karagiannis of the Aristotle University of Thessaloniki told AFP that for the highest doses, "tirzepatide resulted in an average weight loss that was 5.7 kilograms (12.5 pounds) more than semaglutide"

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Preclinically, co-administration of GIP with GLP-1 produces additive and in some measures synergistic reductions in body weight and glucose, more than either alone 25

Continued treatment with tirzepatide for maintenance of weight reduction in adults with obesity: the surmount-4 randomized clinical trial

Patients who engage in structured coaching or cognitive behavioral therapy alongside medication show better adherence and smaller rebound weight gains after discontinuation