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Moreover, a 2021 meta-analysis of five studies that included 868 patients reported that GM1 did not reduce the incidence of grade 2 or higher CIPN or other adverse effects of chemotherapybut also did not reduce therapeutic effects of treatment (Wu 2021)

136 A separate study conducted with mouse models of colon cancer indicated that alternate day fasting for 2 weeks triggered autophagy in cancer cells, which in turn downregulated CD73 expression

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