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Oxidative stress triggers neuroinflammation via NF-B activation, and neuroinflammation further impairs BDNF/TrkB signaling (Yang et al., 2025)

2.2.2 Key driving factors 2.2.2.1 Iron overaccumulation The core driving factor of ferroptosis is the excessive accumulation of iron, and this process is mainly regulated by iron homeostasis regulators such as transferrin receptor (TFR), ferritin, and ferroportin (FPN) (Zhang et al., 2025c)

Ethan Kross: How to Control Your Inner Voice & Increase Your Resilience In this episode, my guest is Dr