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Weight loss is consistently attenuated in patients with T2DM a pattern replicated across the incretin class

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Results vary based on starting weight, adherence to lifestyle changes, and individual metabolism

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Cole K, Woodford C, Alpert N, et al

Intriguingly, one of these studies also showed that longer administrations can lead to a normalization of anxiety and a dissociable improvement in depression-like behavior 158 a pattern that resembles of the mechanisms of action of conventional antidepressants and that may be further suggestive of the activity of GLP-1RAs on the serotonin system 158