Elucidating the regulatory role of miRNAs on pain sensitization, neuropathic pain and the interplay with cognition and behavior alterations in AD, can unleash new resolutions on the pathophysiology of chronic pain in AD
Altered microRNAs related to synaptic function as potential plasma biomarkers for Alzheimer's disease
For instance, evaluating a c peptide index provides medical professionals with vital data regarding endogenous insulin production and metabolic balance
Consistent with negative feedback by p21 on p53 levels (Broude et al, 2007), induction of p21 FL and p21 N , but not p21 C , decreased basal p53 levels and attenuated p53 stabilization upon nutlin-3 treatment, further validating the function of these proteins (Fig 2E)
Effect of oral vitamin C supplementation on serum uric acid: A meta-analysis of randomized controlled trials
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