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Immunity, 46(4), 675689

Conversely, BCAT1 expression is upregulated in certain tumors, potentially promoting tumor growth through glutamate generation, provision of nitrogen sources for nucleotide synthesis, and mTORC1 signaling activation (60)

Evidence note: Among longevity-related peptides, DSIP is one of the most evidence-limited

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Future investigations should focus on large-scale, multicenter clinical trials, and mechanistic studies to clarify pathways of action and define clinical relevance

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