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Regarding the question of what these results tell us about dietary supplementation, this study serves as a reminder of the importance of seeking professional advice when taking supplements

These are cumulative benefits, not overnight changes

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Lighter individuals may experience stronger effects (and more side effects) at each dose level, while heavier individuals may need the full 12mg maintenance dose to achieve optimal results

Instead, it inhibits an enzyme called NNMT, which shifts cell metabolism toward fat oxidation and muscle preservation

Fertil Steril 92:541547