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The effect of the alkyl group, however, can be overcome by increasing the number of hydrophilic functional groups

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EZH2: Enhancer of zeste homolog 2, JNK: Jun N-terminal kinase, H3K4me3: Trimethylated H3 lysine 4, CU17: curcumin derivative, SIRT1: Sirtuin 1, HDAC1,3: histone deacetylase, H2A.X: histone family member X, HDAC: histone deacetylases