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For people whose sleep apnea is severe enough to affect daily functioning, the greater weight loss from tirzepatide or potentially retatrutide could be a deciding factor in medication choice
Let the vial sit at room temperature for 10-15 minutes before injection
Price and access will shape real-world impact
Nausea is common when starting GLP-1 medications but typically improves within 48 weeks
The process is identical for both compounds
Patients who switched from tirzepatide to orforglipron maintained a mean 74.7% of their body weight reduction from the SURMOUNT-5 trial compared with those in the placebo group, which maintained a mean 49.2% of their weight loss
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